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Brigham and Women's Hospital ART Center
Medical Director: Serene Srouji, M.D.
Final Clinic Summary Report for 2020
Retrieval Start Reporting Quartiles
RETRIEVAL START REPORT RATE:67.2 %
Why this matters
RETRIEVAL START REPORT RATE:67.2 %
Why this matters
2160 Total Cycles
25 Embryo Banking for Fertility Preservation
127 Oocyte Banking for Fertility Preservation
0 Donor Oocyte Banking
33 Thaw for Refreeze
44 Delayed Outcome cycles included
69 cycles from 2021 were pulled back into 2020
56 cycles from 2020 were pulled back into 2019
3 Embryo Banking Cycles Converted from Fertility Preservation
4 Oocyte Banking Cycles Converted from Fertility Preservation
Verified by: Medical Director Elizabeth S Ginsburg, M.D.
- Due to the COVID-19 pandemic, some embryo transfers were delayed, leading to a higher number of cycles without a transfer during the 12 months after the retrieval cycle, thereby impacting overall live birth success rates per cycle.
PATIENT'S OWN EGGS
LIVE BIRTHS PER INTENDED EGG RETRIEVAL (ALL EMBRYO TRANSFERS)
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of cycle starts | 356 | 235 | 227 | 108 | 61 |
| Singleton Births | 56.2 % | 38.3 % | 31.7 % | 13.9 % | 8.2 % |
| Live Births | 61.2 % | 43.0 % | 35.7 % | 18.5 % | 9.8 % |
| (Confidence Range) | (56.2 - 66.3) | (36.6 - 49.3) | (29.5 - 41.9) | (11.2 - 25.8) | (2.4 - 17.3) |
| Singleton (percentage of live births) | 91.7 % | 89.1 % | 88.9 % | 75.0 % | 5/6 |
| Twins (percentage of live births) | 8.3 % | 9.9 % | 11.1 % | 25.0 % | 1/6 |
| Triplets or more (percentage of live births) | 0 % | 1.0 % | 0 % | 0 % | 0/6 |
| Term | 86.7 % | 82.2 % | 84.0 % | 90.0 % | 3/6 |
| Pre-term | 11.9 % | 12.9 % | 16.0 % | 5.0 % | 1/6 |
| Very pre-term | 1.4 % | 5.0 % | 0 % | 5.0 % | 2/6 |
| Very pre-term births | N | |
| Pre-term births | N | |
| Term births | N |
| Triplet births | N | |
| Twin births | N | |
| Singleton births | N |
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Cryopreservation Rate | 85.6 % | 72.9 % | 64.6 % | 48.0 % | 35.1 % |
| Mean # of transfers for patients achieving live birth | 1.52 | 1.43 | 1.23 | 1.25 | 1 |
| Number of Transfers | 367 | 193 | 161 | 67 | 38 |
| Mean number of embryos transferred | 1.2 | 1.3 | 1.9 | 2.9 | 3.6 |
| Implantation rate | 42.6 % | 30.9 % | 25.8 % | 10.9 % | 4.4 % |
PATIENT'S OWN EGGS
LIVE BIRTHS PER INTENDED EGG RETRIEVAL (FIRST EMBRYO TRANSFER)
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of cycle starts | 356 | 235 | 227 | 108 | 61 |
| Singleton Births | 37.1 % | 23.8 % | 25.1 % | 10.2 % | 8.2 % |
| Live Births | 38.8 % | 26.8 % | 27.3 % | 14.8 % | 9.8 % |
| (Confidence Range) | (33.7 - 43.8) | (21.1 - 32.5) | (21.5 - 33.1) | (8.1 - 21.5) | (2.4 - 17.3) |
| Singleton (percentage of live births) | 95.7 % | 88.9 % | 91.9 % | 11/16 | 5/6 |
| Twins (percentage of live births) | 4.3 % | 9.5 % | 8.1 % | 5/16 | 1/6 |
| Triplets or more (percentage of live births) | 0 % | 1.6 % | 0 % | 0/16 | 0/6 |
| Term | 89.1 % | 82.5 % | 87.1 % | 14/16 | 3/6 |
| Pre-term | 10.1 % | 11.1 % | 12.9 % | 1/16 | 1/6 |
| Very pre-term | 0.7 % | 6.3 % | 0 % | 1/16 | 2/6 |
| Very pre-term births | N | |
| Pre-term births | N | |
| Term births | N |
| Triplet births | N | |
| Twin births | N | |
| Singleton births | N |
Select # embryos transferred:
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of cycle starts | 356 | 235 | 227 | 108 | 61 |
| Cryopreservation Rate | 85.6 % | 72.9 % | 64.6 % | 48.0 % | 35.1 % |
| % of Cycles with No Transfer | 14.9 % | 26.8 % | 31.7 % | 36.1 % | 31.1 % |
| Number of retrievals | 347 | 221 | 212 | 98 | 57 |
| Cancelled cycles | 2.5 % | 6.0 % | 6.6 % | 9.3 % | 6.6 % |
| Retrievals with no embryos suitable for transfer | 3.2 % | 9.0 % | 7.1 % | 10.2 % | 14.0 % |
| Mean number of embryos transferred | 1.1 | 1.3 | 1.8 | 2.8 | 3.6 |
| eSET % (elective Single Embryo Transfer) | 85.4 % | 68.5 % | 39.1 % | 16.4 % | 13.9 % |
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of cycle starts | 356 | 235 | 227 | 108 | 61 |
| Positive pregnancy test | 56.2 % | 41.7 % | 39.6 % | 36.1 % | 21.3 % |
| Clinical pregnancies | 45.2 % | 32.8 % | 32.2 % | 23.1 % | 14.8 % |
| Miscarriage rate | 14.3 % | 16.9 % | 15.1 % | 36.0 % | 3/9 |
| Number of retrievals | 347 | 221 | 212 | 98 | 57 |
| Live birth per retrieval | 39.8 % | 28.5 % | 29.2 % | 16.3 % | 10.5 % |
| Positive pregnancy test | 57.6 % | 44.3 % | 42.5 % | 39.8 % | 22.8 % |
| Clinical pregnancies | 46.4 % | 34.8 % | 34.4 % | 25.5 % | 15.8 % |
| Number of transfers | 303 | 172 | 155 | 69 | 42 |
| Live birth per transfer | 45.5 % | 36.6 % | 40.0 % | 23.2 % | 14.3 % |
| Positive pregnancy test | 66.0 % | 57.0 % | 58.1 % | 56.5 % | 31.0 % |
| Clinical pregnancies | 53.1 % | 44.8 % | 47.1 % | 36.2 % | 21.4 % |
| Implantation rate | 42.8 % | 32.8 % | 25.5 % | 11.9 % | 4.6 % |
PATIENT'S OWN EGGS
LIVE BIRTHS PER SECOND OR LATER EMBRYO TRANSFER
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of thaw procedures | 234 | 177 | 113 | 32 | 28 |
| Singleton Births | 44.4 % | 43.5 % | 45.1 % | 34.4 % | 14.3 % |
| Live births | 49.6 % | 46.3 % | 49.6 % | 34.4 % | 14.3 % |
| (Confidence Range) | (43.2 - 56.0) | (39.0 - 53.7) | (40.3 - 58.8) | (17.9 - 50.8) | (1.3 - 27.2) |
| Singleton (percentage of live births) | 89.7 % | 93.9 % | 91.1 % | 11/11 | 4/4 |
| Twins (percentage of live births) | 10.3 % | 6.1 % | 8.9 % | 0/11 | 0/4 |
| Triplets or more (percentage of live births) | 0 % | 0 % | 0 % | 0/11 | 0/4 |
| Term | 84.5 % | 86.6 % | 80.4 % | 11/11 | 4/4 |
| Pre-term | 12.1 % | 12.2 % | 16.1 % | 0/11 | 0/4 |
| Very pre-term | 3.4 % | 1.2 % | 3.6 % | 0/11 | 0/4 |
| Very pre-term births | N | |
| Pre-term births | N | |
| Term births | N |
| Triplet births | N | |
| Twin births | N | |
| Singleton births | N |
Select # embryos transferred:
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of cycle starts | 255 | 190 | 125 | 34 | 36 |
| Cancelled cycles | 21 | 13 | 12 | 2 | 8 |
| Number of thaw procedures | 234 | 177 | 113 | 32 | 28 |
| Thaw procedures with no embryos suitable for transfer | 0 | 0 | 0 | 0 | 0 |
| Mean number of embryos transferred | 1.2 | 1.2 | 1.3 | 1.5 | 1.9 |
| eSET % (elective Single Embryo Transfer) | 84.6 % | 83.1 % | 75.7 % | 62.5 % | 40.7 % |
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Positive pregnancy test | 72.2 % | 65.5 % | 71.7 % | 59.4 % | 35.7 % |
| Clinical pregnancies | 58.1 % | 56.5 % | 59.3 % | 50.0 % | 25.0 % |
| Miscarriage rate | 13.2 % | 18.0 % | 10.4 % | 5/16 | 3/7 |
| Implantation rate | 51.1 % | 43.8 % | 46.5 % | 22.9 % | 7.7 % |
PATIENT'S OWN EGGS
LIVE BIRTHS PER NEW PATIENT
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Number of patients | 268 | 136 | 123 | 46 | 26 |
| Singleton Births | 73.9 % | 59.6 % | 51.2 % | 19.6 % | 15.4 % |
| Live Births | 79.1 % | 64.7 % | 59.3 % | 26.1 % | 19.2 % |
| (Confidence Range) | (74.2 - 84.0) | (56.7 - 72.7) | (50.7 - 68.0) | (13.4 - 38.8) | (4.1 - 34.4) |
| Singleton (percentage of live births) | 93.4 % | 92.0 % | 86.3 % | 9/12 | 4/5 |
| Twins (percentage of live births) | 6.1 % | 6.8 % | 13.7 % | 3/12 | 1/5 |
| Triplets or more (percentage of live births) | 0.5 % | 1.1 % | 0 % | 0/12 | 0/5 |
| Term | 87.3 % | 80.7 % | 83.6 % | 10/12 | 2/5 |
| Pre-term | 11.3 % | 14.8 % | 16.4 % | 1/12 | 1/5 |
| Very pre-term | 1.4 % | 4.5 % | 0 % | 1/12 | 2/5 |
| Very pre-term births | N | |
| Pre-term births | N | |
| Term births | N |
| Triplet births | N | |
| Twin births | N | |
| Singleton births | N |
| Age of woman | < 35 | 35 - 37 | 38 - 40 | 41 - 42 | > 42 |
|---|---|---|---|---|---|
| Mean # of attempts at egg retrieval for patients achieving live birth | 1.21 | 1.35 | 1.44 | 1.5 | 1 |
| Mean # of transfers for patients achieving live birth | 1.72 | 1.73 | 1.49 | 1.92 | 1 |
| Number of Transfers | 313 | 137 | 110 | 36 | 22 |
| Mean number of embryos transferred | 1.1 | 1.2 | 1.8 | 2.5 | 3.5 |
| Implantation rate | 43.3 % | 31.6 % | 33.5 % | 11.0 % | 6.5 % |
DONOR EGGS
ALL DONOR EGGS
| Cycle Type | Fresh Donor Eggs | Frozen Donor Eggs | Thawed Embryos | Donated Embryos |
|---|---|---|---|---|
| Number of Recipient Starts/Thaws | 13 | 14 | 42 | 0 |
| Singleton Births | 10/13 | 10/14 | 50.0 % | 0/0 |
| Live births | 10/13 | 11/14 | 52.4 % | 0/0 |
| (Confidence Range) | - | - | (37.3 - 67.5) | - |
| Singleton (percentage of live births) | 10/10 | 10/11 | 95.5 % | 0/0 |
| Twins (percentage of live births) | 0/10 | 1/11 | 4.5 % | 0/0 |
| Triplets or more (percentage of live births) | 0/10 | 0/11 | 0 % | 0/0 |
| Cycle Type | Fresh Donor Eggs | Frozen Donor Eggs | Thawed Embryos | Donated Embryos |
|---|---|---|---|---|
| Number of transfers | 12 | 14 | 42 | 0 |
| Mean number of embryos transferred | 1.1 | 1.2 | 1.1 | - |
| eSET (elective Single Embryo Transfer) | 11/12 | 10/13 | 92.9 % | 0/0 |
| Failed Cycles Intended for Embryo Freezing | 0 | N/A | N/A | N/A |
| Donor Cycles Intended for Embryo Cryopreservation | 8 | N/A | N/A | N/A |
| Implantation rate | 10/13 | 12/17 | 51.1 % | 0/0 |
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Filter Report
Loading ...insert_chart Understand This Report
This report is designed to provide patients with outcomes that reflect the way infertility is treated through IVF. By tracking the outcome of cycles initiated for egg retrieval over a two-year period, this report accounts for both fresh and frozen embryo transfers resulting from the egg retrieval cycle. We hope this will help you better understand the expected outcomes from Assisted Reproductive Technologies (ART). If you want to get a more personalized prognosis for your chances, please visit
the SART patient predictor.
The SART Clinic Summary Report (CSR) allows patients to view national and individual clinic IVF success rates. The data presented in this report should not be used for comparing clinics. Clinics may have differences in patient selection and treatment approaches which may artificially inflate or lower pregnancy rates relative to another clinic. Please discuss this with your doctor.
What is the difference between a Preliminary and Final CSR and why are some cycles delayed?What is a cycle?
A cycle is counted when a woman has started medications for the purpose of having an ART procedure. In the case of a “natural” cycle when no medications are used, the cycle starts with the first day of a woman’s menstrual cycle when she is planning to have an ART procedure done that month. The cycle is counted if an egg retrieval is performed or if the cycle is cancelled before the egg retrieval. If several cycles are performed to bank eggs or embryos, each will be counted in the denominator when calculating the pregnancy rate. For example, if three successive ovarian stimulation cycles are performed with the purpose of accumulating or “banking” embryos for one embryo transfer later that year that results in a delivery, the delivery rate would be 1/3 (33%). We feel that counting each cycle and not just focusing on the embryo transfer more accurately reflects the treatment burden and costs the patient has endured.
What is considered a “success”?
In this report, we have emphasized the delivery of a child (rather than a positive pregnancy test) as the main outcome of interest, since this is the outcome patients desire. We also have emphasized singleton deliveries since twin and higher order multiple pregnancies have a higher risk of premature delivery and have increased medical complications during the pregnancy and after delivery, often with infants requiring stays in the neonatal intensive care unit. Cycle success is measured by the live birth rate with a singleton delivery occurring after 37 weeks of gestation being the optimal outcome of IVF cycle. The percentage of triplet, twin and singleton births contributing to the live birth rate are provided for each cycle group and a summation of all deliveries (singletons and multiple births) is provided in the report. We have also reported the risk of premature delivery by dividing the live births into three groups including delivery occurring before 32 weeks of gestation (very pre-term), 32-37 weeks of gestation (pre-term) or reaching term (>37 weeks).
Outcomes are divided by several factors including patient age and source of the eggs whether autologous (originating from the female patient) or donor eggs. These are important prognostic factors and by separating the data, you can get a better idea of both national and individual clinic experience by these factors. The report contains additional filters for infertility diagnosis, stimulation type and other treatment details are available for patients to review the number of procedures and outcomes for specific patient groups and treatments.
Patient’s Own EggsAll Embryo Transfers
Also called the "cumulative live birth rate", this reflects the chance of achieving a live birth after a fresh or frozen embryo transfer within a year of cycle initiated for egg retrieval. The live birth may have been the result of the first embryo transfer (fresh or frozen) or a frozen embryo transfers that occurs after the first attempted transfer (secondary or subsequent transfer). The 2014 reporting year was the first year that subsequent cycles were linked to the egg retrieval cycles to generate the cumulative live birth rate per egg retrieval cycle.
First Embryo Transfer
A cycle is initiated for egg retrieval. This cycle is concluded with the outcome of the first embryo transfer (fresh or frozen embryos) or it has been determined that embryo transfer will not be performed within a year of the egg retrieval cycle start. This is also called the "Primary Outcome".
If an embryo transfer occurred, the FIRST EMBRYO TRANSFER may be attributed to either a fresh or frozen embryo transfer. If you wish to review primary outcomes from fresh embryo transfers, use the FILTER feature and exclude frozen embryo transfers. If you wish to review Primary Outcomes from cycles where no fresh embryo transfer occurred and the outcome is from the 1st frozen embryo transfer, use the FILTER feature and include only frozen embryo transfers.
Live Births Per Second or Later Embryo Transfer (2021 and Earlier)
Also called the "Subsequent Outcome," this table includes any cycle involving the thawing of eggs or embryos after the Primary Outcome has been determined. This is the cycle that is started either after the first embryo transfer has occurred or if more than one year has passed since the egg retrieval and this cycle is the first egg or embryo thaw.
Second Embryo Transfer (2022 and Later)
Also called the "Secondary Outcome," this table includes cycles involving the thawing of eggs or embryos for the second attempted transfer within 1 year of the initial retrieval cycle, after the Primary Outcome has been determined.
Live Births Per Additional Transfers/Long Term Freezes (2022 and Later)
Also called the "Subsequent Outcome," this table includes any cycle involving the thawing of eggs or embryos after the Primary or Secondary Outcome has been determined. This also includes cycles that are started either after the first and second embryo transfer has occurred or if more than one year has passed since the egg retrieval and this cycle is the first egg or embryo thaw, as well as cycles that do not have a linked retrieval entered in the system.
Live Births Per New Patient
The live birth rate per new patient includes the outcomes for patients who are new to an infertility center and starting their first cycle for retrieval of their own eggs during the reporting year.
ADDRESS & HOURSBrigham and Women's Hospital, 75 Francis Street, # Tower 5C
Boston, MA 02115
(617) 732-5570
SERVICES & PROFILEPractice Director: Rachel K Ashby
Medical Director: Serene Srouji, M.D.
Laboratory Director: Kathryn Go, Ph.D.
SART Member
Verified Lab Accreditation
Services:
Donor Egg
Donor Embryo
Gestational Carriers
Embryo Cryopreservation
Egg Cryopreservation
Female Couple
Male Couple
Single Men
Single Woman
PGD/PGS
Mental Health Services
HIV Patients
Ovarian Tissue Cryopreservation
PATIENT SEVERITY INDEXWhy we don't provide information on patient characteristics per clinic:
It is understandable that patients would like to use SART clinic outcome reports both as a “report card” to judge quality of care and as a predictor of chance of success for each individual patient. Currently, the SART clinic summary reports cannot be used without context for either purpose.